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KMID : 0385219950050010025
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Korean Journal of Gerontology
1995 Volume.5 No. 1 p.25 ~ p.29
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Glycation of Dicarbonyl Compounds on Lysozyme at Low Oxygen Concentration
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Yang Ryung
Eum Sung-Yong
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Abstract
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Dicarbonyl compounds formed from glycation of proteins has been known as modifier or cross-linker of macromolecules in vivo. Glyoxal, methylglyoxal and glutaraldehyde identified in most glycation reaction were incubated with lysozyme under physiological condition. These dicarbonyl compounds accerated both polymerization and loss of activity but reduced browning irrespective of oxygen concentrations. In the case of ascorbic acid which is in meed of oxidation to dehydroascorbic acid, dicarbonyl compounds for reaction with proteins, the glycation of lysozyme was markedly inhibited by low oxygen concentration. These results suggests that dicarbonyl compounds as cytotoxic glycation intermediates may contribute to proteins modification in vivo and the glycation process after formation of dicarbonyl compound may be not effected by oxygen concentration
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KEYWORD
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glycation, dkcarbonyl compound, low oxygen concentration, lysozyme
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